How a Tree Grows - A Brief Overview

Little of a trees volume is actually living tissue. Just 1% of a tree is actually alive and composed of living cells. The major living portion of a growing tree is a thin film of cells just under the bark (called the cambium) and can be only one to several cells thick. Other living cells are in root tips, the apical meristem, leaves, and buds. The overwhelming portion of all trees is made up of non-living tissue created by a cambial hardening into non-living wood cells on the inner cambial layer. Sandwiched between the outer cambial layer and the bark is an ongoing process of creating sieve tubes which transport food from leaves to roots. So, all wood is formed by the inner cambium and all food-conveying cells are formed by the outer cambium. Apical Growth Tree height and branch lengthening begin with a bud. Tree height growth is caused by the apical meristem whose cells divide and elongate at the base of the bud to create upward growth in trees with a dominant crown tip. There can be more than one developing crown if a trees top is damaged. Certain conifers cannot produce these growth cells and height growth stops at the crown tip. Tree branch growth works in a similar way using buds at the apex of each twig. These twigs become the future branches of trees. Transfer of genetic material in the process will cause these buds to grow at determined rates, creating a tree species height and form. Tree trunk growth is coordinated with the increase of tree height and width. When buds begin opening in the early Spring, cells in the trunk and limbs get the signal to increase in girth by dividing and in height by elongating. Root Cap Growth Early root growth is a function of meristematic root tissue located near the tip of the root. The specialized meristem cells divide, producing more meristem called root cap cells which protect the meristem and undifferentiated root cells while pushing through the soil. The undifferentiated cells become the primary tissues of the developing root during elongation and the process that pushes the root tip forward in the growing medium. Gradually these cells differentiate and mature into specialized cells of the root tissues.

The Effect Of Stress On The Immune System - 1186 Words

1. Discuss the impact of stress on the immune system. Stress has a huge impact on the immune system. The immune system is interconnected. For example the immune, nervous, and endocrine system is linked through specialized communication pathways involving hormones, neurotransmitters, neuropeptides, and immune cell productions. Stress reactions can directly affect the various response systems and how they handle the neuroendocrine-products. This stress reaction directly affects the hypothalamus and pituitary peptides through the sympathetic branch of the autonomic nervous system. Some of these stressors might be life events, anxiety, and excitements. The human body reacts externally or internally in the way of physiological responses. When we experience one of these stressors the physiological responses job is to prepare the body to deal either by adapting to it or simply surviving it. This can promote a functional alteration in the organs normal function. These changes can include how the immune cells function. By one reducing the natural killer cells and T cell cytotoxicity or by impairing the B cell function. By affecting these cells it can have dire health consequences like weakening the immune systems defense. In an acute stressor, the immune system is heightened. But is suppressed in a chronic stressor. In this situation the cortisol levels rise, and weaken the immune system. This weaken system can make the human body more susceptible to serious disease, infectionsShow MoreRelatedThe Effect Of Physiologic Stress On The Immune System1495 Words   |  6 PagesThere is a huge impact on the immune system when stress occurs. Physiologic stress is a chemical or physical disturbance produced by change in the external environment or within the body that brings out a response to offset that disturbance. Three components of physiologic stress include the exogenous or endogenous stressor initiating the disturbance, the chemical or physical disturbance produced by stressor and the body’s counteracting adaptation response to disturbance. Stressors include pain,Read MoreThe Effects Of Cortisol Mediated Chronic And Acute Stress And Immune System Response2571 Words   |  11 PagesChronic and Ac ute Stress and Immune System Response Introduction The nervous, endocrine, and immune systems share a close relationship critical to maintaining homeostasis during psychological and immune stress (Carlsson, Anneli, Ludvigsson, Faresjà ¶, 2014). Chronic stress, primarily mediated by the glucocorticoid cortisol, is associated with deleterious health outcomes and immune deficiency. However, acute stress is associated with protective health effects and immune enhancement. Stress has generallyRead MoreEssay on The Effect of Stress on Cardiovascular Disorders1190 Words   |  5 PagesThe Effect of Stress on Cardiovascular Disorders A cardiovascular disorder is any disorder effecting the heart and circulatory system. There is evidence that links stress plays a role in the development of two types of cardiovascular disorders, hypertension (high blood pressure) and coronary heart disease (CHD), which reduces the flow of blood to the heart. Stress may directly cause cardiovascular problems by; rising heart rate which wears the lining of the blood vesselsRead MoreOutline and Evaluate Research Into the Relationship Between the Immune System and Stress Related Illness827 Words   |  4 Pagesrelationship between the immune system and stress related illness The main function of the immune system is to protect the body from infectious agents such as viruses and other toxins. The immune system can fail us in two ways-either by becoming under-vigilant, letting infections enter the body, or over-vigilant, so that it is the immune system itself, rather than an infectious agent that causes illness. Most studies of the relationship between stress and the immune system have focussed on acute(iRead MoreStress And The Immune System Essay828 Words   |  4 PagesStress And The Immune System The immune system is a very important part of our bodily functions as its main function is to protect the body against millions of antigens, which attack our cells and try to reproduce viruses and diseases. The immune system can protect the body in three different ways, in which are: 1. It creates a barrier that prevents the antigens from initially entering the body. 2. If the antigens do manage to enter the body, then yourRead MoreThe Link Between Psychological Stressors and Overall Health Essay1544 Words   |  7 Pagesstressors and a persons’ overall health have been proven through various objective studies. The degree of the stress response can also be directly linked to the severity of its effects. Specific research indicates that stress is related to increased risk of improper immune system functioning, liver disease, and coronary artery disease. When exposed to environmental threats, the body’s immune system carries out dynamic processes through the secretion of various chemicals and production of various kindsRead MoreA Relationship Between Stress and Physical Illness Essay1078 Words   |  5 PagesA Relationship Between Stress and Physical Illness Stress is an example of a behaviour and experience explained in physiological and psychological terms. Recently awareness has been heightened concerning the harmful effects of stress and how it can be successfully managed and prevented. Lay definitions of stress seem to focus on a force or some kind of mental pressure which is exerted upon an individual which is aversive. Stress is often associated with anxietyRead MoreHuman Therapeutic Ways Of Addressing Cancer Treatment866 Words   |  4 Pagesof NSCLC. However, this can no longer be viewed as a discovery but a wave in the medicine world that began in the 20th century. Various researchers have found the importance of the role of immune systems in fighting the growth of tumor caused by cancer cells. A study by Huncharek (2000) stated that specific immune boosters are capable of eliminating preclinical cancers. In contrast, Jermal et al. (2011) found that immunotherapy is an effective approach for the treatment of tumors that have alreadyRead MoreThe Pathology Of A Newly Diagnosed Cancer Patient Than The Well Differentiated Ones900 Words   |  4 PagesCatecholamine The two are stress hormones. They are normally released to give the fight response or the flight one. These two responses are common when one is under stress. They accomplish this common task by releasing appropriate chemicals and sending various signals to the brain and nervous system. Their differences arise in the type of actions they trigger in the body. Catecholamine leads to heart activities, as well as those of the kidney and blood vessels. Its effects include changing glucoseRead MoreThe Effects Of Optimism On Cancer Survival Rate926 Words   |  4 Pagesthe inner mechanisms of the effects of optimism on cancer survival rate. Salovey (2000) has proposed various potential casual pathways from dispositional optimism to cancer survival outcomes. One of the potential mediators of optimism and survival outcome might be immune system. In other words, optimism tends to enhance the immune system which in turn enhance cancer survival rate. Indeed, Ah (2007) examines the intimate conn ections among social support, optimism, and immune response. Ah hypothesized

Antigone Character Sketch Essay Example For Students

Antigone Character Sketch Essay Antigone, the character for which the play was named, is a very complex character. She seems to change directions all throughout the play and there is never one point in which you know exactly what she will do because she is just that unpredictable. This unpredictability also makes her seem very hypocritical because she will say something and then turn on a dime and say the complete opposite. Antigones character is very intriguing strictly due to the fact that she keeps you guessing. The following will show the many variations that her character shows throughout the play. There are several points in the play that Antigone seems very heroic, especially when she is speaking to Creon about her reasoning for attempting to bury her brother. She reflects every aspect of a hero by trying to sneak out not once, but twice and then even more by standing up to Creon. All of these heroics, however, in a very short time make her look very selfish. After Creon tells her the story about her brothers bodies, she takes the stance that she must bury her brother for herself. That all but erases the thought of her, as a hero because all of her actions that were thought to have been done for Polynices were only done to satisfy her own needs. The one characteristic of Antigone that seems to be constant throughout the play is her stubbornness. From the beginning of the play when she sneaks out to bury her brother after Creon had specifically told her not to, all the way to the end when she is given the opportunity to marry Haemon and go on living but forces her own death. She always seemed to fight everything for as long as possible, never taking the easy way out if it compromised her beliefs. In the end it was her stubbornness that ultimately killed her. Antigone also attempts to come across as the so-called innocent victim. When she is first found out and Creon confronts her, she pushes the fact that she had to do it for Polynices. Even when that reason went to hell and she changed her story to say that she had to bury him for herself, she still said she was bound to do it, which represents Antigone trying to make herself look innocent by saying she had to do it. I do not think there is a right or wrong answer as to whether she was an innocent victim or not, but the question is posed all throughout the play. Of all Antigones characteristics, it seems as though her stubbornness is the most prevalent of all. The fact that she is stubborn is only the beginning of the description of her character. Antigone is by far the most complex of all the characters in the play and I think it is safe to say that none even come close to her. I believe that the variations in her character also make her the most interesting  of all the characters because with the others you know what to expect. Antigone is an amazing play and the title character is as amazing as she is complex.

Martin Luthers Translation of the Bible

Martin Luther, the once devoted Catholic, one day came across a bible hidden in one of the apartments of Erfurt University library. Upon reading the book keenly, Luther encountered significant differences between what his Catholic Church taught and what the bible said concerning issues like relying on the church fathers for the remission of sins. Since the church teachings were contrary to the bible teachings, he got concerned and protested the issues, hence becoming the father of Protestantism.Advertising We will write a custom essay sample on Martin Luther’s Translation of the Bible specifically for you for only $16.05 $11/page Learn More As a working criterion of spreading the truth, as it stands in the bible, Luther took the boldest step ever of translating his newly found bible into vernacular languages, German for instance, an issue that angered the Catholic Church as more people left the church to follow Luther’s teachings. The trans lation plays a very important role to the German history. Initially, the Germans could not tell lies from the truth based on the then teachings, which were presented in foreign languages other than their understandable vernacular language. In addition, they had hungered for reformation for long and thus the translation seemed important as it marked the dawn of that awaited reformation. In fact, Shaff points out that â€Å"The spread of this version, imperfect as it was, proves the hunger and thirst of the German people for the pure word of God, and prepared the way for the Reformation† (Para. 9). In addition, the translation was so important in that it solved the problems of the majority of Germans who, despite their little education, wanted to know the truth but could not get it from the former complicated bible. Sanders observes, â€Å"†¦even tailors and shoemakers, yea, even women and ignorant persons†¦studied it with the greatest avidity as the fountain of all truth† (Para. 2). Further, the translation assisted the common people who, through the easy reading and understanding of the true word of God, could then make informed decisions concerning the truth. In other words, Luther’s work was no more than a force that fuelled the freedom of the Germans. The evident Protestant state churches of Germany, initially used by Luther to teach his cohorts, aroused the courage of teaching to the Germans. Besides, the Lutheran bible is of great significance to the German history.Advertising Looking for essay on history? Let's see if we can help you! Get your first paper with 15% OFF Learn More Luther’s translation of the bible into German marked the most outstanding revolving point of the Germans’ history. For instance, its high rate of spreading across the Germans stands out as the origin of the advanced German language. Initially, the language featured so many dialects such that the people could neither under stand nor unite with one another. Therefore, Luther, through his works restored this harmony of language and further forming the basis of the contemporary German literature. The translation too fuelled the famous reformation of religion. In fact, it was through the translation that Protestantism emerged, which was otherwise nowhere before. Further, the Lutheran bible contributed significantly towards â€Å"the creation of German nationalism because†¦his sayings and translation became part of the German national heritage† (Gerhard 216). The translation too contributed towards the reformation of the German education system. The reformation came as Luther campaigned for the education of every person, which in turn left virtually all Germans in a position of reading and understanding the bible. Internationally, Luther’s translation significantly fuelled the widening of Protestantism as many other people who supported Luther came up with some other translations like th e King James Version, the Bishop’s Bible, and the Douay-Rheims Bible among others. Therefore, as evidenced by the expositions, Luther’s translation of the bible into vernacular German language stands out as both important and significant the Germans history. It marked the dawn of reformation in Germany as people demanded to hear and know the truth, as revealed by the word of God. Further, it induced the courage of teaching by the Germans and more so teaching the true pure word of God in a language that even the illiterate could understand. As a result, the translation is the root of all the protestant churches, not only in Germany, but also in the world at large. Works Cited Gerhard, Ritter. Luther: His Life and Work. New York: Harper and Row Publishers, 1963.Advertising We will write a custom essay sample on Martin Luther’s Translation of the Bible specifically for you for only $16.05 $11/page Learn More Sanders, Ruth. How Martin L uther’s Translation of the Bible Influenced the German  Language, 2010. Web.  https://liturgical.wordpress.com/2010/09/01/how-martin-luthers-translation-of-the-bible-influenced-the-german-language/ Shaff, Phillip. History of the Christian Church. New York: Charles Scribner’s Sons, 1910. This essay on Martin Luther’s Translation of the Bible was written and submitted by user Al1s0n to help you with your own studies. You are free to use it for research and reference purposes in order to write your own paper; however, you must cite it accordingly. You can donate your paper here.

How to Find Greatest Common Factors

How to Find Greatest Common Factors Factors are numbers that divide evenly in a number. The greatest common factor of two or more numbers is the largest number that can divide evenly into each of the numbers. Here, you will learn how to find factors and greatest common factors. You will want to know how to factor numbers when you are trying to simplify fractions. What You Need Manipulatives: Coins, buttons, hard beansPencils and paperCalculator Steps Factors of the number 12: You can evenly divide 12 by 1, 2, 3, 4, 6 and 12.Therefore, we can say that 1,2,3,4,6 and 12 are factors of 12.We can also say that the greatest or largest factor of 12 is 12.Factors of 12 and 6: You can evenly divide 12 by 1, 2, 3, 4, 6 and 12. You can evenly divide 6 by 1, 2, 3 and 6. Now, look at both sets of numbers. What is the largest factor of both numbers? 6 is the largest or greatest factor for 12 and 6.Factors of 8 and 32: You can evenly divide 8 by 1, 2, 4 and 8. You can evenly divide 32 by 1, 2, 4, 8, 16 and 32. Therefore the largest common factor of both numbers is 8.Multiplying Common Prime Factors: This is another method to find the greatest common factor. Lets take 8 and 32. The prime factors of 8 are 1 x 2 x 2 x 2. Notice that the prime factors of 32 are 1 x 2 x 2 x 2 x 2 x 2. If we multiply the common prime factors of 8 and 32, we get 1 x 2 x 2 x 2 8, which becomes the greatest common factor.Both methods will help you determine the greates t common factors (GFCs), but you will need to decide which method you prefer to work with. Manipulatives: Use coins or buttons for this concept. Lets say youre trying to find factors of 24. Ask the child to divide the 24 buttons/coins into 2 piles. The child will discover that 12 is a factor. Ask the child how many ways they can evenly divide the coins. Soon they will discover that they can stack the coins into groups of 2, 4, 6, 8, and 12. Always use manipulatives to prove the concept. Tips Be sure to use coins, buttons, cubes, etc. to prove how finding factors works. Its much easier to learn concretely than abstractly. Once the concept is grasped in a concrete format, it will be much more easily understood abstractly.This concept requires some ongoing practice. Provide a few sessions with it.

Scorpion Fish Facts (Scorpaenidae)

Scorpion Fish Facts (Scorpaenidae) The term scorpion fish refers to a group of ray-finned fishes in the family Scorpaenidae. Collectively, they are called rockfish or stonefish because they are bottom dwellers camouflaged to resemble rocks or coral. The family includes 10 subfamilies and at least 388 species. Important genera include the lionfish (Pterois sp.) and stonefish (Synanceia sp.). All scorpion fish have venomous spines, giving the fish their common name. While stings can be fatal to humans, the fish are not aggressive and only sting when threatened or injured. Fast Facts: Scorpion Fish Scientific Name: Scorpaenidae (species include Pterois volitans, Synaceia horrida)Other Names: Lionfish, stonefish, scorpionfish, rockfish, firefish, dragonfish, turkeyfish, stingfish, butterfly codDistinguishing Features: Compressed body with wide mouth and conspicuous, venomous dorsal spinesAverage Size: Under 0.6 meters (2 feet)Diet: CarnivorousLife Span: 15 yearsHabitat: Coastal tropical, subtropical, and temperate seas worldwideConservation Status: Least ConcernKingdom: AnimaliaPhylum: ChordataClass: ActinopterygiiOrder: ScorpaeniformesFamily: ScorpaenidaeFun Fact: Scorpion fish not aggressive. They only sting if they are threatened or injured. Description The scorpion fish has a compressed body with ridges or spines on its head, 11 to 17 dorsal spines, and pectoral fins with well-developed rays. The fish come in all colors. Lionfish are brightly colored, so potential predators can identify them as a threat. Stonefish, on the other hand, have mottled coloring that camouflages them against rocks and coral. The average adult scorpion fish is under 0.6 meters (2 feet) in length. Except for lionfish, scorpion fish have a mottled coloration that serves as camouflage. LITTLE DINOSAUR / Getty Images Distribution Most members of the Scorpaenidae family live in the Indo-Pacific, but species occur worldwide in tropical, subtropical, and temperate seas. Scorpion fish tend to live in shallow coastal water. However, a few species occur as deep as 2200 meters (7200 feet). They are well-camouflaged against reefs, rocks, and sediment, so they spend most of their time near the sea floor. The red lionfish and common lionfish are invasive species in the Caribbean and Atlantic Ocean off the coast of the United States. The only effective method of control to date has been NOAAs campaign of Lionfish as Food. Encouraging consumption of the fish not only helps control lionfish population density, but also helps protect overfished grouper and snapper populations. Reproduction and Life Cycle Female scorpion fish release between 2,000 and 15,000 eggs into the water, which are fertilized by the male. After mating, the adults move away and seek cover to minimize attention from predators. The eggs then float to the surface to minimize predation. Eggs hatch in after two days. The newly-hatched scorpion fish, called fry, remain near the surface until they are around about an inch long. At this time, they sink to the bottom to seek a crevice and begin hunting. Scorpion fish live up to 15 years. Diet and Hunting The carnivorous scorpion fish preys upon other fish (including other scorpion fish), crustaceans, mollusks, and other invertebrates. A scorpion fish will eat virtually any other animal that can be swallowed whole. Most scorpion fish species are nocturnal hunters, while lionfish are most active in the morning daylight hours. Some scorpion fish wait for prey to approach. Lionfish actively hunt and attack prey, using a bilateral swim bladder to precisely control body position. To catch prey, a scorpion fish blows a jet of water toward its victim, disorienting it. If the prey is a fish, the jet of water also causes it to orient against the current so that its facing the scorpion fish. Head-first capture is easier, so this technique improves hunting efficiency. Once the prey is positioned correctly, the scorpion fish sucks in its prey whole. In some cases, the fish uses its spines to stun prey, but this behavior is fairly uncommon. Predators While its likely that predation of eggs and fry is the primary form of natural population control of scorpion fish, its unclear what percentage of scorpion fish young are eaten. Adults have few predators, but sharks, rays, snappers, and sea lions have been observed hunting the fish. Sharks appear to be immune to scorpion fish venom. Although scorpion fish are venomous, they are gentle animals. This diver is feeding a lionfish. Justin Okoye / EyeEm / Getty Images Scorpion fish arent fished commercially because of the risk of stings. However, they are edible, and cooking the fish neutralizes the venom. For sushi, the fish may be eaten raw if the venomous dorsal fins are removed before preparation. Scorpion Fish Venom and Stings Scorpion fish erect their spines and inject venom if they are bitten by a predator, grabbed, or stepped on. The venom contains a mixture of neurotoxins. Typical symptoms of poisoning include intense, throbbing pain that lasts up to 12 hours, peaking in the first hour or two following the sting, as well as redness, bruising, numbness, and swelling at the sting site. Severe reactions include nausea, vomiting, abdominal cramps, tremors, decreased blood pressure, shortness of breath, and abnormal heart rhythms. Paralysis, seizures, and death are possible, but are usually restricted to stonefish poisoning. The young and elderly are more susceptible to the venom than healthy adults. Death is rare, but some people are allergic to the venom and may suffer anaphylactic shock. Australian hospitals keep stonefish anti-venom on hand. For other species and for stonefish first aid, the first step is to remove the victim from water to prevent drowning. Vinegar may be applied to reduce pain, while the venom may be inactivated by immersing the sting site in hot water for 30 to 90 minutes. Tweezers should be used to remove any remaining spines and the area should be scrubbed with soap and water and then flushed with fresh water. Medical care is required for all scorpion fish, lionfish, and stonefish stings, even if the venom appears to be deactivated. Its important to be certain that no spine remnants remain in the flesh. A tetanus booster may be recommended. Conservation Status Most species of scorpion fish have not been evaluated in terms of conservation status. However, the stonefish Synanceia verrucosa and Synanceia horrida are listed as least concern on the IUCN Red List, with stable populations. The luna lionfish Pterois lunulata and red lionfish Pterois volitans are also least concern. The population of red lionfish, an invasive species, is increasing. While no significant threats face scorpion fish at this time, they may be at risk from habitat destruction, pollution, and climate change. Sources Doubilet, David (November 1987). Scorpionfish: Danger in Disguise. National Geographic. Vol. 172 no. 5. pp. 634–643. ISSN 0027-9358Eschmeyer, William N. (1998). Paxton, J.R.; Eschmeyer, W.N., eds. Encyclopedia of Fishes. San Diego: Academic Press. pp. 175–176. ISBN 0-12-547665-5.Morris J.A. Jr., Akins J.L. (2009). Feeding ecology of invasive lionfish (Pterois volitans) in the Bahamian archipelago. Environmental Biology of Fishes. 86 (3): 389–398. doi:10.1007/s10641-009-9538-8Sauners P.R., Taylor P.B. (1959). Venom of the lionfish  Pterois volitans.  American Journal of Physiology.  197: 437–440Taylor, G. (2000). Toxic fish spine injury: Lessons from 11 years experience. South Pacific Underwater Medicine Society Journal. 30 (1). ISSN 0813-1988

French Revolution During 18th Century Essay Example | Topics and Well Written Essays - 2000 words

French Revolution During 18th Century - Essay Example (Lind Frey, 2004) The immediate cause of revolution was financial crisis that originated due to war in America that was financed through borrowing by Necker and same method was adopted by Calonne to pay off the arrears which increased the deficit. Fiscal administration was so confusing that the rough analysis of financial statements of March 1788 of Old Regime budget estimated expenditures at about 629 million livres and receipts of 503 million leaving behind the deficit of 126 million or 20% which was attributed to court wastefulness and financers profit. The emptied treasury resulted in cutbacks of pension and stockholders Bank of Discounts were made legal tender. (Georges Lefebvre, Elizabeth Moss Evanson and Paul H. Beik) Ronald Schechter presents the argument of Furet wherein it is mentioned that the revolution of 1787 marked the first capitulation of the state to the demands of the sharing the power between the administrative officials and elected representatives of third estate s. (Ronald Schechter, 2001) Kings under capability of handling the situation of crisis after the war made him a weaker leader. Louis XVI was not able to control the deficit and adopted the same method that Necker used to finance the war in America. And moreover the new taxation policy by imposing the tax on elite groups like notables, and other merchants ignited the sense of revolt among the Third Estate members to which they disagreed. These factors sparked the beginning of revolution in France. The revolt from elite groups created an excitement among the commoners, notably lawyers and they supported the nobles in revolt against king even though he was authorizing them to plead his case. The Patriot Party was formed which provoked counter argument using brochures with cautious... This essay describes the French Revolution, that was the major event during the 18th century that shook the entire world and economy of France. It laid the foundation for human rights through Declaration of the Rights of Man which provided equal status to poor and downtrodden on par with nobles and clergy. It was the Estates General meeting called by Louis XVI to elect the deputies that led the revolt among the Third Estate. The revolt intensified when Third Estate broke the stalemate and spread the revolt across France inviting First and Second Estate to join the rebel. The peasants’ war broke out resulting in loss of human life. Aftermath of the revolution, the French government implemented various provision and policies to cope with the economic crisis. The French revolution had various effects in forms of economy, society, political and religion. There were no differences maintained in the state school and government authorized the positions of pastor and bishops. France r eceived dramatic response from neighboring countries in the form of war including America. It also promoted nationalism which was also adopted by Italy and Germany under Napoleon and influenced most of the European countries to adopt parliamentary democracy. Such was the impact of the revolution that evolved the democratic form of government which is followed almost by all the countries in world today giving equal rights and opportunity to each and every citizen irrespective of race, religion, social and financial status.

Presentation Essentials IP Week 5 Essay Example | Topics and Well Written Essays - 750 words

Presentation Essentials IP Week 5 - Essay Example The examples listed in the topic discussion give real evidence on some of the successful entrepreneurs that have managed to apply interesting business ideas. For instance, it mentions Magic Johnson who used his savings from the property he got from the repairs he made after buying a house. The intended audiences for the topic discussions include; business personnel and entrepreneurs who are aiming at making huge profits from their savings and money meant for business (Howell-Carey & Carey, 2004). Research sources My research sources on the topic include; ‘Learning About Lakefront Property by United States Environment Protection’ ‘The New Path To Real Estate Wealth by Chantal Howell Carey and Bill Carey’ and ‘Legal Aspects of Owning and Managing Woodlands by Thom Mcevoy’ (United States Environment Protection, 2012). The research resources have been useful in giving noteworthy tips of selling and owing income property through using significant bus iness ideas. For instance ‘learning about lake front property states ways an individual discovers pertinent idea of investing on the properties he/she possess either through buying or selling. Other sources states various ways a person can invest on the properties he/she has to generate maximum profits from them. ... The body section highlights on the importance of dealing with focused renters since they determine whether a business person dealing with the process of buying the property will be successful (United States Environment Protection, 2012). Further, a business entrepreneur ought to focus on incredibly low opportunity when purchasing low cost rental property. The author of the book advises business personnel having 20 to 30 dollars to invest in income property and find a suitable location for the business. On the next part, the section of the discussion states a real life example that states the importance of looking what the future holds; it is important to prepare amicably. The appropriateness and effectiveness of your visual aids The visual aids are important in assisting the audience comprehends the concept of the topic being discussed. Hence, I was forced to use visual aids such as charts; graphs and sign language to express and explain my point out valiantly and easily. For example , the charts had good images that showed the audience the best properties to look for when purchasing them. It is important for them to choose something good that will satisfy them (United States Environment Protection, 2012). The audience were able to see the statistics on the properties discussed easily hence making them aware on the expenditure they apply when purchasing them. The visual aids were attached on a mini billboard that was easy to be shown to the audiences easily. The effectiveness of your presentation The effectiveness of my presentation was that I managed to teach and edify the audience on the topic I was discussing; which was ‘The Positive Points of Owning

House of Mirth by Edith Wharton Essay Example for Free

House of Mirth by Edith Wharton Essay The House of Mirth is separated into two books of approximately equal length, with Book I having at least thirty more pages than the other. In the commencement of Book I, the central character, who goes by the name of Lily Bart is twenty-nine years old and gets acquainted with the fact that she is on the threshold of losing her influence to hang about in society by the desirable quality of her looks and charisma alone. She believes that getting married is her only way out. The itinerary of Book I describe Lily’s tribulations in accomplishing this goal. By the end, Lily has continued to exist after an attempted rape which nonetheless hurts her repute and causes her to be unable to find the high regard of Lawrence Selden and is desperately in liability. Book II, commences in Monte Carlo with additional and given up for lost scandal, moves to New York and additional debt. It ends in deficiency, lonesomeness, and an unintentional death that could without difficulty be called a suicide. Similarities The story presented by Edith Wharton is rather tragic. It is about a beautiful, high-spirited woman who is in dire need of getting over the manipulations of others and the extremely stern society around her. The only assets that the central character Lily has are her beauty and charisma. She is well-acquainted with the rules of the upper class New York society of 1905. Lily tells Lawrence that, a girl must [get married] and a man if he chooses†. (Wharton, p. 165) Lily basically is totally dependant on her aunt for her financial expenses and believes that she should get married to a wealthy man as soon as possible. But, as she confesses, she always does the right thing at the wrong time. She is nearly married to about three different men who are pretty wealthy but she is not able to go ahead with it. She is in love with Lawrence, but considering the fact that he is not rich and has to work to make both ends meet, she does not even let herself imagine that she should marry him. She comprehends the susceptibility of her position she does not have any fortune of her own, and for that reason her reputation must be impeccable. The people that she is surrounded by have minds like moral flypaper they can forgive a woman anything but the loss of her good name. Unfortunately, Lilys inherent honesty makes it impossible for her to realize the treachery and desperation around her. She makes some foolish choices: We resist the great temptations, but it is the little ones that eventually pull us down. (The House of Mirth, p. 1). In both the movie and the book, perhaps her only mistake is that she ends up trusting all the wrong people. Because of this we can see in the movie and the novel that her reputation is looked down upon and she ends up owing a great deal of money to a man who misused her trust and made attempts to ruin her reputation. As is said, we witness in the movie that â€Å"by the time she is willing to accept the proposal of businessman Sim Rosedale (Anthony LaPaglia), he is no longer willing to offer her the position of wife, only mistress. Rosedale has a kind heart, and he likes Lily. But he is a businessman with ambitions of being fully accepted into society, and he can see that Lily is damaged goods. Perhaps her very willingness to accept him makes her less appealing† (The House of Mirth, p. 1). Lily realizes the sensitivity of her position in the society and she realizes that nothing she does would be right for her after she has been betrayed by nearly everyone and is shunned aside by her society. She now makes attempts in both the movie and the novel to support herself first as secretary/companion to a vulgar social-climber, then as an internee in a millinery shop. She makes one last exaggerated plea for help from her cousin, and also comprehends a drastic attempt at blackmail, but that is a great temptation she is able to resist. The movie definitely is a great adaptation of the novel written by the author with first-rate performances and extravagant details of that period. Edith Whartons 1905 The House of Mirth, apparently is a novel about early-20th century New York upper classes, and is really an outer-space story, and instinctively at least, the director Terence Davies seems to know it. In order to Whartons book to the display, Davies takes care to get all the accouterments right: the depressively sparkling balls and social gatherings of turn-of-the-century Manhattan society life, the faux-rustic lavishness of the nation state homes of the rich, the odd rules and regulations and subtexts prowling behind the way a woman might trip her delicately gloved hand into that of a man. In Whartons view, and in Davies, it is an ambiance that is hospitable on the exterior but fastened with fatal gas, an accurate arrangement of molecules that looks for and finds and strangles the life out of foreign creatures, like Whartons great conqueror Lily Bart, who need air and brightness and love. It takes one beautiful alien to play Bart. Davies The House of Mirth is not anything like a science-fiction movie, for sure, apart from the way it uses ambiance to communicate a sneaking pastiness of claustrophobia and even danger. What is evident from the first frame, just like it is evident in the beginning of the novel by Wharton, is that Lily is a human being who just does not fit in this world. What is worst is that she herself believes and is convinced with this fact. The deception of the story, nevertheless, is that we are not in actuality sure about the origin of Lily; Whartons wrapping up is that there are no definable monetary, communities or devout divisions that are moderately right for her, and Davies movie, with all its miserable sophistication, incarcerates the real meaning of that peripatetic restiveness. A gorgeously beautiful but spinster woman of twenty-nine with deteriorating prediction, Lily has been raised to accept as true that luxury is exactly what she deserves. Hence, Lily lives further than her means, relying for the most part on the resentful contributions of her elderly aunt, Mrs. Peniston. All the lacking that Lily suffers because she does not have money, she makes up for in behavior of verbal communication and coquetry: she has the ability as well as the charm to turn any encounter into an enticing meeting. Nevertheless her game playing, as Wharton has written and as Anderson plays it, is not entrenched in heartlessness. It is more a particular kind of non-interventionist resourcefulness, such that her possible love interest and a little bit retribution Lawrence Selden are overwhelmed by it. I always like to see what youre doing, he tells her only half-teasingly. Youre such a wonderful spectacle. (Wharton, p. 35) To keep herself buoyant economically, Lily is desperately in need of a husband, but she is disastrous in finding one due to the fact that, deep down, she knows she does not want one. She is most involved with Selden, a legal representative of self-effacing means who lives for books and fine art and a warm fire. But not even Selden is a sanctuary for her considering that he proves himself competent of devastating coldness. And after Lily unsuspectingly puts herself in a negotiative position with a married friend, Gus Trenor, she comes to realize that she will have to make her own money to support herself. The movie presents to us that Whartons book is not an assembling cry for womens expressive and financial self-government. It is far more understated, and a lot less joyful, than that. But the narrative repetitively affirms the worth of that self-determination, exclusively by showing us how tantalizingly it is kept out of poor Lilys reach. The movie incarcerates something of Whartons reticent tenderness and attractive rhythms in the way it sets Lily revolving on her unhurried spiral to calamity. The movie takes a few emancipations with the story, concentrating, for example, two of Whartons innovative characters into one. The movie House of Mirth is a dignified movie, sometimes too much so, moving with the momentum and sprightliness of a dowager aunt and the channel of communication, much of it taken straight from the novel is from time to time stiff and discomfited. But the movie does an unimpeachable job of screening to us, in the first half of the movie, both the mesmerizing comforts and the tediousness of the life Lily desires to, with its seamless drawing rooms and unnaturally effervescent parties. The second half is shadowy and more visually solemn, as Lily thrashes about to keep her existence together. But that pessimism makes it obvious that this less-glamorous continuation is not right for Lily, either. She can be considered an exotic bird, in poor condition for the filth and dirt of the everyday world but far too unexpected to be serving tea to rich, unintelligent gentlepeople. Lily, too contemporary, too fundamental and too beautiful, fits nowhere, in no detailed society, time or place (Zacharek, p. 1). Edith Wharton plots The House of Mirth on a sequence of meetings set in vibrantly distinct social settings. The first communal setting is Lawrence Selden’s residence at the Benedict and the convention is between him and Lily Bart. The second is the Trenors’ country house throughout a week-long party. In the pinnacle, Wharton shows with great power the sexual operation at the heart of the financial dependence of women. In the increasing action, Wharton sets up the rudiments of Lily Bart’s personality by showing her in stroke in a social situation which restrains her choices. In the lessening action, when Lily Bart has been evicted from the society that has prearranged her values, Wharton shows that Lily Bart is not ready to become accustomed to a dissimilar way of life. Lily Bart becomes a disastrous figure; trying with her imperfect moral possessions to live up to her intellect of what is right, even when it means facing impoverishment (Wharton, p. 25). Conclusion In the light of the above discussion we can hereby culminate that the movie and the novel namely The House of Mirth written by Edith Wharton has much in common.

Long and Short Term Causes of WWI :: World War I History

Long and Short Term Causes of WWI There were several long-term events that led to the outbreak of World War One. The most prominent factors include: nationalism, militarism, imperialism, the Balkan and Morocco crises, and the alliance system. Ironically, these things were either started in response to, or upheld because of, one of the other factors. The alliance system was one of the last factors to emerge before the war. Consequentially, the contributions of this system to the beginning of the Great War have to be considered. Although the alliance system was a main cause of the First World War, it arose because of several other factors, and did not cause the war single handedly. Nationalism, the love and support of one's country, has always existed. In this era, however, it was to take part in the creation of one of the most famous wars in history. Since so much pride was devoted to countries, it made the possibilities of peace between past rivals less probable. It also meant that most nations, especially the great powers, would rather fight a war than back down from a rival's diplomatic provocation. In effect, nationalism was also a contributing factor to the alliance system. No country feels comfortable being in a war alone, and with the growing militaries in almost every country, allies provided much comfort. The supreme present of militarism, "a policy of aggressive military preparedness" , in this period of time gave all countries great reason to feel the heavy weight of an oncoming war. Great Britain's naval policy (to always be twice as big as the next two largest navies put together), along with the predominate feeling of war provided countries with a strong reason to try and create an incredibly strong military force. This led to an arms race, which made the impending war seem inevitable. The military planning in some countries also caused an increased fear of war. Since military machines were being developed, each country was appointing a general staff of experts. The greatest problem with this was that there was a fear that "some chief of staff, in order to maintain the schedule on his 'timetable', might force an order of mobilization and thus precipitate war." These two factors also led, in part, to the alliance system. If two or more countries are allied with each other then the y have a better chance of defeating their common enemy if war is declared.

Is it possible to distinguish between science and pseudo-science? Essay

Introduction: For starters let us try to define both terms. Science is an organized, disciplined, unbiased search for knowledge for the world around us. Remember, Science does not discover facts, but rather finds statements (theories, formulae, descriptions) as a result of having examined the real world. These statements describe what may be expected to be found under stated conditions. Note, science is always prepared to adjust, reverse, abandon and/or subtract to/from its statement, in order to more closely approach the truth: The truth being an unreachable goal, which we will eventually and essentially get to (Randi, Internet). Pseudo-science is an established body of knowledge which tries to pass itself as science. It tries to claim legitimacy that it would not otherwise be able to do on its own. We can also call it fringe or alternative science. It basically lacks the carefully and thoughtfully interpreted experiments which provide the foundation of the natural sciences. Incidentally, this is what contributes to its advancement. A vital point to emphasize is that a body of knowledge is used because science involves elements of intuition and guesswork. In regard to this therefore we discover a major weakness in utilizing the experiments approach in science. This comes about because experiments do not always test a theory adequately, moreover results can be incorrectly interpreted or in cases be plain wrong. In legitimate science, these problems tend to be self correcting, through critical scrutiny by the original researcher of the greater scientific community (Chem1, Internet). Pseudo means fake. Thus, the surest way to spot a fake is to know as much as possible about the original, genuine or the actual science itself. Forthwith, it is of critical importance to understand the nature of science. This will include getting to grips with the criteria of evidence, the design of meaningful experiments, the weighing of possibilities, the testing of hypotheses, the establishment of theories and the many aspects of scientific methods that make it possible to draw reliable conclusions about the physical universe (Quakewatch, Internet). Having said this we ask, is there really a fine line between real science and pseudo-science? And if so, where does it lie? From an initial inspection, it is plain to see that these two are as opposite as rationality and religion are. Whereas we use basic principles such as objectivity and accuracy to establish a finding, we also use in science certain admitted assumptions about reality. These, though, eventually do support themselves; they become proven or result in false verification thus discarded. Pseudo science on its part will utilize invented modes of analysis which substitute for meeting the requirements of scientific method, though they basically violate the essential attributes. It’s easy to identify many examples of these, but it is the more subtle and insidious and convincing cases that require better definition of the attributes involved (Randi, Internet). The quest to clearly identify and determine the line dividing science and pseudo-science is indeed daunting. This is because the media has so much muddled the waters that we are, in instances, compelled to think what we see or hear in the media is the truth. It is wise to remember that, pseudo-science transcends all fields of science. Not one field is safe. For example, in the field of physics [and by extension, other natural sciences] the following are cases (Quackwatch, Internet) that have been used to try and unmask pseudo-science: †¢ It is common the find proponents of pseudo-science referring to work many years old. Unlike science were literature is updated every other year (latest editions) to take into consideration the rapid accumulation of new facts and insights, pseudo-scientists will rarely revise. †¢ This point above exposes pseudo scientists to the intense criticism of holding on to bogus facts proposed many years ago. It has been found that they research by relying on newspaper clippings, hearsay, ancient religions or mythological works as their point of fact. They never bother to perform independent investigation to check their source. †¢ Also they are fond of beginning with a hypothesis. Usually, this hypothesis is very emotionally appealing and spectacularly implausible. After the emotionally appealing hypothesis has been fronted, they then look for supporting evidence. Should any conflict be identified it is quickly ignored or rationalized. †¢ They ignore or misrepresent genuine scientific fact. Pseudo-scientists will instead rely on unverifiable eyewitness testimony, stories, tales, hearsay, rumor and dubious anecdotes. They will invariably rely heavily on subjectivity validation. Newspaper horoscope describes astrology perfectly making many people believe in them. But on close examination, it is found they describe generalities enough to cover virtually everyone (Quackwatch, Internet). No pseudo-scientist who was shouting on the roof top at the beginning of the year offering/ putting forward predictions and hypothesis will be found to analyze how many of them came to pass at the end of the year (Chem1, Internet). This is unlike science where all principles must be tested and remain continually questioned or rejected over time. In pseudo-science, such predictions or hypothesis are not often falsifiable and are equally unlikely to ever be altered or shown to be wrong. This is erroneously taken by proponents as evidence of validity. Where as scientific explanations must be stated clearly in unambiguous terms, this is the opposite in pseudo-science. They often invoke scientific terms in dubious context. For example, ‘energy vibrations’ and ‘subtle energy fields’ sound impressive but are essentially meaningless terminologies (Chem1, Internet). Looking at the case of Electromagnetic frequency for instance, f or a long time pseudo-scientists fronted a case for its likelihood to be associated with causing the onset of cancer. Communities leaving near power lines and also electricians were deemed to be most at risk of contracting cancer in this way. However, after substantive review of existing literature and interview of specialists in the field, it was found that the statistical evidence for a correlation between the two was negligible and growing smaller. Even in the case of electricians, no effort was made to eliminate other factors before placing an accusing finger at high voltage power lines by the pseudo-scientists. Further, pseudo scientists offer little or no theoretical explanation of how such electromagnetic fields [EMF] can actually produce cancer (Csicop, Internet). On the other hand, science is its own worst enemy. It allows stifling of orthodoxy of beat ideas. Science has the tendency of forgetting that many of the best ideas in human history began as heresies. Comparisons between bizarre claims and science as it is actually practiced will show that no sharp division can be established (Math, Internet). Forget the various checklists given to distinguish the two[i. e. science and pseudo science], as none perfectly achieves this. The disagreements and disparities are more to be found on the finer points. Even the most hardened skeptic does not deny the possible validity of paranormal phenomena. It is necessary to point out at this juncture that, the fathers of science; Einstein and Newton, considered today as geniuses, were in their age actually considered heretics. What they chose to bring forward as science was so much against the norm then, that nobody dared believe them. They did not produce their revolutionary ideas in one moment of brilliance as propagated by scientists (findarticles. com).

Plato learning analyzing speeches Essay

Teacher-Graded Activities Write a response for each of the following activities. Check the Evaluation section at the end of this document to make sure you have met the expected criteria for the assignment. When you have finished, submit your work to your teacher. 1. Comparing Speeches a. Read President Lincoln’s Gettysburg Address and Martin Luther King Jr.’s I Have a Dream speech. What emotions do you feel while reading these speeches? What elements of the speeches evoke these emotions? Type your response here: The Gettysburg address strikes emotion in everyone, due to the person who wrote it and due to the subject matter. The Gettysburg address evokes happiness, sadness, and pride in our country, In the speech Lincoln makes many references to the was that had happened, and he also makes many reference to how great America, which makes people think that everything will be alright and that the country is strong enough to endure this civil war. As for Martin Luther King Jr.’s speech it invokes completely different emotions such as shame in our country and sadness, the elements that invoke these emotions are King’s way of speaking, the way he references Lincoln, and the fact that he remains hopeful even though hope seems to be lost. b. Do you notice any similarities between President Lincoln’s speech and Martin Luther King Jr.’s speech? What are the similarities? Why do you think King drew parallels between his speech and Lincoln’s? Type your response here: King gave his speech on the steps of the Lincoln memorial, as if to honor Lincoln for the strong and brave way that he tried to abolish slavery, and his accomplishment of it, and yet King still feels as if he is enslaved due to strong oppression of black people. Both Lincoln and King invoke strong emotions of hope, and patriotism. I believe that king drew parallels between his speech and Lincolns to A: Grab the attention of everyone who hears him, and B: to commemorate Lincoln, and to make it known that he is proud of Lincoln and thankful to him for all of his hard work. c. Think about the audience that President Lincoln was addressing with the Gettysburg Address and about the audience that Martin Luther King Jr. was addressing with his I Have a Dream speech. Describe each audience, and explain how the speeches reflected, and were appropriate for, their audiences. Type your response here: Lincoln was addressing the families of soldiers, the citizens of the untied states, and maybe even foreign countries. I believe Lincoln chose these audiences to show that he still supports everyone even though the battle going on was so brutal, I also believe that he chose families of soldiers to assure them that the deaths, and lives of soldiers are not taken for granted and to assure them that it was all worth it in the end. As for King, His audience was mostly towards as he called them â€Å"Negros,† I believe strongly that King chose this Audience to tell them that there is still hope for equality between white and black people, because there truly was, and still is thanks to King. Kings Audience is very appropriate because he himself was black and was fighting for the rights of everyone he was speaking to. 2. Rhetorical Devices a. Revisit the Gettysburg Address and I Have a Dream. As you read, list the rhetorical devices that you notice: state the device, define it, provide an example of it from the speech, and explain its emotional impact. Type your response here: The Gettysburg Address Rhetorical Device Definition Example Emotional Impact Epithet A descriptive adjective attached to a noun to evoke an idea or emotion. â€Å"Now we are engaged in a great civil war.† It invokes the fear of the war, and the fact that the civil war was bigger than expected. Asyndeton A list that omits conjunctions between items. â€Å"we can not dedicate — we can not consecrate — we can not hallow — this ground† it adds to the flow of the speech and holds my attention Antanagoge Placement of a negative point next to a positive on in a way that downplays the negative â€Å"The brave men, living and dead, who struggled here, have consecrated it†¦but it can never forget what they did here.† It makes one feel like the men who died will never be forgotten and gives hope to the families. I Have a Dream Rhetorical Device Definition Example Emotional Impact Sententia A famous quotation, maxim, or wise saying Five score years ago. It draws the attention of the audience and makes them think about what the topic is. Anadiplosis Repetition of the last word of a sentence or phrase near thebeginning of the next sentence or phrase Repitition of â€Å"I have a Dream† at the end. It keeps the attention of audience, and it also invokes a feeling of hope in the audience, through King’s dream. Epithet A descriptive adjective attached to a noun to evoke an idea or emotion tragic fact that the Negro is still not free Adding the word tragic to fact envokes a feeling of hopelessness and the feeling of needing to fix the tragedy. Asyndeton A list that omits conjunctions between items. guaranteed the inalienable rights of life, liberty, and the pursuit of happiness. The Asydeton makes it so people are hanging onto everyword, and keeps the attention. Personification Human attributes given to non-human objects and ideas. America has defaulted on this promissory note insofar as her citizens of color It makes America seem more relatable by everyone. b. Listen to one (or more) of the readings of the Gettysburg Address. Did you notice any rhetorical devices when listening to the speech that you did not notice when you read the speech, and vice versa? Do the rhetorical devices have a different effect when they are spoken as opposed to read? Explain your response. Type your response here: I did not hear anymore rhetorical devices in other readings of the Gettysburg address. However the rhetorical devices seem to stand out more when they are read because they have the full emotion of the voice to display them, thus making it more emotional and understandable. c. Listen to Martin Luther King Jr.’s I Have a Dream speech. What differences did you notice between the way the Gettysburg Address and I Have a Dream were delivered? Which rhetorical devices were more effective in each speech? Type your response here: I have a dream was delivered with more emotion than the Gettysburg address, I suppose it is because of the subject matter, Human rights seem to be more important than war and hate, and yet both speeches used wonderful rhetorical devices, In the Gettysburg address the use of the antanagoge is very prominit because it helps to ensure that they will never be forgotten. In I have a dream uses the rhetorical device of anadiplosis was strongly effective as King repeated ‘I have a dream’ at the very end of the speech. d. Were you able to recognize the rhetorical devices in I Have a Dream when listening to it? Was it easier for you to recognize them as you heard them or as you read them? Why? Type your response here: I was unable to identify any more rhetorical devices in the I Have a Dream speech, however it was easier to identify the rhetorical devices due to the emotion that I referenced earlier. 3. Analyzing Speeches a. Review the Gettysburg Address and I Have a Dream. What organizational pattern does each speech utilize? Do you see evidence of more than one type of pattern present in either speech? Give examples of the patterns in the speeches, and explain why the organizational pattern used is or is not the most effective. Type your response here: â€Å"I have a dream† has a spatial order This worked because Martin Luther king Jr. was basically going through a timeline about the rights of black people. The Gettysburg address is in Topical order, and this worked because Lincoln was speaking in segments about the war. b. Describe which elements of the introductions of the speeches, if any, are notably attention grabbing. Type your response here: Both speeches begin notably, for Lincoln’s it begins with â€Å"four score and  seven years ago.† and similarly king’s speech begins with â€Å"five score.† both are extremely memorable. c. Do the speeches answer the questions Why should I care? and How does this topic relate to me? Support your response with examples. Type your response here: Both speeches answer these questions in their own way. Lincoln used an appeal to the countries citizens an example of this was â€Å"We are met on a great battle-field of that war. We have come to dedicate a portion of that field, as a final resting place for those who here gave their lives that that nation might live† As for Martin Luther King Jr. he answered those questions by saying â€Å"This momentous decree came as a great beacon light of hope to millions of Negro slaves who had been seared in the flames of withering injustice. It came as a joyous daybreak to end the long night of their captivity.† as he was speaking to his audience who are fighting for their freedom just as he was. d. Do the speakers provide their objectives for their speeches within their introductions? Provide examples with your answer. Type your response here: â€Å"I am happy to join with you today in what will go down in history as the greatest demonstration for freedom in the history of our nation.† this is the very very first line In I have a dream, it shows that he is expecting this speech to go into history for being the best example of freedom. In the Gettysburg address there was not a clear objective other than trying to honor those who have died in the war. e. Do the speakers use any supportive devices, such as humor or repetition, in their speeches? Give examples of any such devices. Type your response here: Martin Luther King Jr. relied on repetition strongly during the end of his speech saying â€Å"i have a dream† repeatedly to prove his point f. How would you describe the conclusions of the speeches? Do they summarize their objectives and end with impact? Explain. Type your response here: The end of both of these speeches summarize the point of their speeches and they definitely end with an impact. Lincolns speech ends by validating that the country will not die simply because of the war it was in at the time, and King’s speech ends with king saying what he dreams will happen, meaning he ends talking about equality between blacks and whites. g. List some of the transitions and signposts used in each speech. Type your response here: Lincoln: â€Å"Now we are engaged in a great civil war† â€Å"But, in a larger sense,† â€Å"It is rather for us, the living† King: â€Å"And if America† â€Å"And as we walk,† â€Å"But there is something that I must say† 4. Speech Writing a. Write a speech on any subject from this list of speech ideas. Remember that your speech will need to be two to four minutes long. Type your response here: Many people today talk about the sanctity of marriage. This belief is part of the reason why many people believe that gay marriage should not be legalized in America. To these people I pose the question, is marriage really all that sacred in this country and would letting anyone who wants to enter into same sex marriage make it not so? In my opinion, people like Britney Spears and anyone else who will jump into a Los Vegas 3-day wedding, are the people who are destroying the sanctity of marriage. In addition to the negative ideas  about gay marriage, there are other problems concerning same-sex couples such as adoption between same sex couples, In 2012, 110,000 children live with gay parents, that may seem like a large number but in all actuality that is about 1% of the child population that live in U.S households. I understand that there is quite an opposition to same sex parents raising children because people say that children need a mother and father figure to grow up properly, an yet there are approximately 13.7 million single parents in the United States today, and those parents are responsible for raising 22 million children, and no one truly comments on that causing any problems with the way the children grow up. In this speech i outlined a few problems that i believe we need to fix about same-sex couples, Because people should be able to marry whoever they wish and take care of children like normal families that i honestly believe they already are. B. Describe your speech writing and presentation experience. Type your response here: writing this speech was quite easy for me considering gay rights is a topic that i am very passionate about because my sister and my best friend are both gay. In addition to the passion, i had experience analyzing speeches thanks to this lesson, and it was quite fun to write especially in since i know what the structure of a good speech is. as for presenting it, i presented it to QCAD on the day of silence, and it was very well received. Evaluation Your teacher will use these rubrics to evaluate the completeness of your work as well as the clarity of thinking you exhibit. Activity 1: Comparing Speeches Concepts Distinguished (4 points) Accurately points out the connection between emotions invoked and the elements of the two speeches Accurately and exhaustively points out similarities between the two speeches Supports answers convincingly by stating facts, giving logical reasons, and using examples Accurately describes the target audiences Proficient (3 points) Adequately points out the connection between emotions invoked and the elements of in the two speeches Accurately points out several similarities between the two speeches Supports answers well by stating facts, giving logical reasons, and using examples Somewhat accurately describes the target audiences Developing (2 points) Points out the connection between emotions invoked and the elements of the two speeches with a few errors Points out similarities between the two speeches with a few errors Supports answers by stating facts, giving logical reasons, and using examples Loosely describes the target audiences Beginning (1 point) Fails to point out the connection between emotions invoked and the elements of the two speeches Fails to point out many notable similarities between the two speeches Does not support answers with adequate examples or reasoning Vaguely or incorrectly describes the target audiences Activity 2: Rhetorical Devices Concepts Distinguished (4 points) Lists multiple examples of rhetorical devices in both speeches Thoroughly explains the emotional impact of each rhetorical device in the speeches Thoroughly interprets the different effects of rhetorical devices in the written and oral forms of the speeches Accurately evaluates the  effectiveness of the rhetorical devices in both speeches Supports answers convincingly by stating facts, giving logical reasons, and using examples Proficient (3 points) Lists adequate examples of rhetorical devices in both speeches Adequately explains the emotional impact of each rhetorical device in the speeches Reasonably interprets the different effects of rhetorical devices in the written and oral forms of the speeches Reasonably evaluates the effectiveness of the rhetorical devices in both speeches Supports answers well by stating facts, giving logical reasons, and using examples Developing (2 points) Lists very few examples of rhetorical devices in both speeches Explains the emotional impact of each rhetorical device in the speeches with a few errors Interprets the different effects of rhetorical devices in the written and oral forms of the speeches with a few errors Evaluates the effectiveness of the rhetorical devices in both speeches with a few errors Supports answers by stating facts, giving logical reasons, and using examples Beginning (1 point) Lists incorrect examples of rhetorical devices in both speeches Fails to explain the emotional impact of each rhetorical device in the speeches Fails to correctly interpret the different effects of rhetorical devices in the written and oral forms of the speeches Fails to correctly evaluate the effectiveness of the rhetorical devices in both speeches Does not support answers with adequate examples or reasoning Activity 3: Analyzing Speeches Concepts Distinguished (4 points) Accurately and exhaustively identifies examples of organizational patterns used in each speech Accurately and exhaustively identifies examples of attention-grabbing elements in each speech Accurately and exhaustively identifies examples of supporting devices used by the speakers in each speech Thoroughly describes the conclusion of each speech Accurately and exhaustively identifies examples of transitions and signposts used in each speech Provides thorough and accurate reasoning by stating facts, giving logical reasons, and using examples Proficient (3 points) Accurately identifies multiple examples of organizational patterns used in each speech Accurately identifies multiple examples of attention-grabbing elements in each speech Accurately identifies multiple examples of supporting devices used by the speakers in each speech Adequately describes the conclusion of each speech Accurately identifies multiple examples of transitions and signposts used in each speech Provides accurate reasoning by stating facts, giving logical reasons, and using examples Developing (2 points) Correctly identifies examples of organizational patterns used in each speech Correctly identifies examples of attention-grabbing elements in each speech Correctly identifies examples of supporting devices used by the speakers in each speech Roughly describes the conclusion of each speech Correctly identifies examples of transitions and signposts used in each speech Provides somewhat accurate reasoning by stating facts, giving logical reasons, and using examples Beginning (1 point) Does not identify examples of organizational patterns used in each speech Does not identify examples of attention-grabbing elements in each speech Does not identify examples of supporting devices used by the speakers in each speech Vaguely or incorrectly correctly describes the conclusion of each speech Does not identify examples of transitions and signposts used in each speech Fails to provide accurate reasoning to support answers Activity 4: Speech Writing Concepts Distinguished (4 points) Uses language that is most suitable for the intended audience Keeps the speech clear and maintains a slow pace throughout Uses appropriate devices to grab the audience’s attention Uses effective reasoning to connect the audience’s interests to the topic Effectively maintains focus on the main points throughout the speech Effectively uses supporting devices such as facts, statistics, examples, and testimony Effectively uses transitions between topics to keep the audience connected Uses an effective and relevant concluding sentence Includes thoughtful reflections on the speech-writing experience Proficient (3 points) Uses language that is appropriate for the intended audience Keeps the speech somewhat clear and maintains a slow pace throughout Uses largely appropriate devices to grab the audience’s attention Uses somewhat effective reasoning to connect the audience’s interests to the topic Maintains focus on the main points through the speech Uses supporting devices such as facts, statistics, examples, and testimony Effectively uses a few transitions between topics to keep the audience connected Uses a somewhat effective and relevant concluding sentence Includes moderately thoughtful reflections on the speech-writing experience Developing (2 points) Uses language that is somewhat appropriate for the intended audience Is barely able to keep the speech clear and does not maintain a steady pace Uses somewhat appropriate devices to grab the audience’s attention Uses reasoning to connect the audience’s interests to the topic Barely maintains focus on the main points through the speech Uses supporting devices such as facts, statistics, examples, and testimony with a few errors Uses somewhat  effective transitions between topics to keep the audience connected Uses a relevant concluding sentence Includes some reflections on the speech-writing experience Beginning (1 point) Uses language that is inappropriate for the intended audience Fails to keep the speech clear or maintain a slow pace Does not use any devices to get the audience’s attention Fails to connect the audience’s interests to the topic Loses focus on the main points Does not uses supporting devices such as facts, statistics, examples, and testimony Fails to use transitions between topics to keep the audience connected Uses a concluding sentence that is neither effective nor relevant Includes minimal reflections on the speech-writing experience

Case Study Week6 Example

Case Study Week6 Example Case Study Week6 – Case Study Example PATAGONIA REPORT Patagonia is a region endowed with an affluent culture. Hosting various inhabitants such as baqueano, Aonikenk and Kaweskars, Patagonia has a culture not beaten by many. Maslow’s hierarchy describes various basic needs using the terms self-actualization, esteem, love, safety and physiological. According to Maslow, human motivation moves through these basic needs. The Patagonia culture meets two of hierarchy’s basic needs, love and esteem. The Patagonia’s baqueano culture meets the basic need of love. According to the Maslow’s hierarchy love, in humans involves a feeling of belongingness and acceptance. In the baqueano’s culture, it is evident that the baqueanos promoted the feeling of acceptance and belongingness. This is seen in the 1870s where the baqueano horsemen guided explorers who arrived in Patagonia. By doing this, the baqueano promoted the feeling of acceptance between them and the explorers. Esteem revolves around respect . Guiding the explorers showed deep respect to them, and thus the Patagonian culture met the basic need of esteem.Working at Patagonia involves dedicating your time and energy to work while getting no compensation. This causes one become de-motivated and thus lowers the quality of work delivered. Patagonia’s work environment lacks the basic needs described by the Maslow’s hierarchy and thus working in the company is strenuous. (Becoming a Responsible Company, n.d, 2014)According to equity theory of motivation, underpayment of an employee leads to the employee becoming hostile to the employer. If a Patagonia workers feels underpaid, then he or she will become hostile and rebellious to the manager. This will lead to a clash between the employee and the manager that will lead to the employee delivering low-quality work. To increase the employees’ motivation Patagonia’s manager should introduce a monthly salary to the employees. (Becoming a Responsible Compan y, n.d, 2014). Lack of payment is the greatest challenge facing Patagonia’s employees’ motivationRecommendationIf I was the manager of Patagonia’s employees in a retail shop, to keep them motivated, I would introduce a monthly salary, give them gifts and lastly promote the employees who work well.Referencesn, d. (2014). Becoming a Responsible Company. Retrieved from Patagonia: patagonia.com/us/patagonia.go?assetid=1963n, d. (2014). Cultural preservation. Retrieved from Ecocampus: ecocamp.travel/Sustainability/Cultural-Preservation

45 Idioms with Roll

45 Idioms with Roll 45 Idioms with Roll 45 Idioms with Roll By Mark Nichol Roll, ultimately derived from the Latin noun rota, meaning â€Å"wheel,† is the basis of numerous idioms about movement, many of which are listed and defined below. 1. a rolling stone gathers no moss: a proverb meaning that one who remains active will not become complacent or hidebound 2–4. get rolling or get/start the ball rolling: get started 5. heads will roll: said in reference to a reckoning, such as a mass firing at a business, alluding to decapitations such as those that occurred during executions by guillotine after the French Revolution 6. let it roll: an exhortation to make something move or allow it to move 7. let the good times roll: an expression perhaps originating with (and directly translated from) the Cajun French saying â€Å"Laissez les bons temps rouler,† associated with Mardi Gras 8–9. let’s rock and roll/roll: slang exhorting others to join in starting an endeavor 10. on a roll: a reference to being on a lucky streak 11. ready to roll: prepared 12. roll along: a reference to smooth operation 13. roll around: slang for â€Å"arrive or occur again,† as in the case of an anniversary 14–15. roll back/rollback: return to a previous state; an act of returning to a previous state 16–17. roll back the clock/years: a reference to going back in time 18. roll by: move past, as in a reference to the passage of years 19. roll call: reading of a roster of names to determine who is present in a group 20. roll (one’s) eyes: a reference to the expression one makes to signal annoyance, derision, or disbelief 21. roll in: appear or arrive, especially in large amounts or numbers 22. roll in the hay: a euphemism for sex, from the notion of a pile of hay in a barn being used in lieu of a bed 23. roll off the tongue: a reference to how easily or awkwardly a word, phrase, or expression can be spoken depending on the juxtaposition of consonants and vowels 24–25. roll out/rollout: introduce something, such as a product; an act of introducing something 26. roll out the red carpet: a reference to providing an elegant experience, from the association with red carpets set out at the entrance to an exclusive event 27. roll out the welcome mat: show friendliness and hospitality 28–29. roll over/rollover: reinvest; a reinvestment 30. roll over and play dead: idiom related to surrendering or to feigning death 31. roll over in (one’s) grave: a reference to how a revered deceased person would be agitated if he or she were to become reanimated and be aware of how something associated with that person has supposedly become degraded (spin is sometimes used as an intensifier of â€Å"roll over†) 32. roll the bones/dice: a reference specifically to casting dice in the gambling game of craps or in general to taking one’s chances 33. roll up (one’s) sleeves: a reference to preparing to work hard, from the notion of protecting shirtsleeves from materials that may damage or soil them or of ensuring that they do not get caught in machinery 34. roll up in: slang referring to someone approaching in a distinctive vehicle (one that is described subsequent to the phrase) and coming to a stop 35. roll up the sidewalks: a jocular reference to the lack of nightlife in small towns, with the notion that sidewalks are put away at a certain time each night because there is no longer any foot traffic 36. roll with it: said as advice to someone to accept, and perhaps take advantage of, a situation 37. roll with the punches: adjust to difficulties, from boxing slang for moving as a punch is delivered toward one to minimize the impact 38. rolled into one: a reference to something having multiple purposes or uses 39–41. rolling in dough/it/money: said of someone wealthy 42. rolling in the aisles: said in reference to something extremely amusing, from the notion that audience members at a performance are laughing to the extent that they fall out of their seats and tumble into the aisles 43–44. rolling on the floor/rolling on the floor laughing my ass off: a reference, usually abbreviated ROTFL/ROTFLMAO, to one being so amused that one falls to the floor and rolls around, laughing helplessly; the latter phrase is an intensifier 45. rolling stone: a restless or itinerant person Want to improve your English in five minutes a day? Get a subscription and start receiving our writing tips and exercises daily! Keep learning! Browse the Expressions category, check our popular posts, or choose a related post below:30 Synonyms for â€Å"Meeting†75 Idioms and Expressions That Include â€Å"Break†Adverbs and Hyphens

Determination the Role of the US in War Research Paper

Determination the Role of the US in War - Research Paper Example It tends to be forgotten that war affects all people in a nation. Not just the soldiers who fight on the front lines or their families who must deal with their absences and deaths, but everyone living within that nation. In his speech, Charles Lindberg declared the importance of listening to the nation as a whole as it is the whole nation who is subjected to war and not just a few individuals. This opinion has altered the way that war is viewed. Instead of war being an act of simple revenge, fighting regardless of the outcome, war has become a game that we, as players on the same team, must win. To successfully win, we have to remember the entirety of our nation when we consider starting or entering the war. The position of the United States in war has led to a vital development in society, one in which every person’s opinions, through voting, are taken to heart and the majority wins. As Lindberg stated, â€Å"There is no better way to give comfort to an enemy than to divide the people of a nation over the issue of foreign war.†1 When a nation finds itself in its own battle with citizen pinned against citizen, they are only making themselves easier targets for their enemies. Should they enter a war with their own drama, they stand no chance at winning. When Lindberg gave his speech, he was providing the United States with one of the most effective methods of success that this nation can have when subjected to war: unity. This is why America boasts of its democracy, and it shows especially during times of war.  

Is apple iPhone really worth buying Essay Example | Topics and Well Written Essays - 2000 words

Is apple iPhone really worth buying - Essay Example 2. Procedure In order to gather information for this report the method used was the review of books from academic libraries, online journals, newspaper articles and reviews given on IPhone and competing mobile devices. This is the most appropriate method bearing in mind the smart phone industry is very dynamic and the internet is the only reliable source of up to date information. Moreover, there being little time to carry out a primary research and the high expenses associated with it, literature review was the most appropriate secondary research method. 3. Introduction on IPhone Inc In 2007, Apple, under the leadership of Steve jobs introduced the IPhone which turned out to be one of the most revolutionary mobile gadgets of the century, over the course of the next two years; the IPhone 3G was also launched into the smartphone market (Richie, 2013). The devices offered better technology at significantly reduced prices and effectively took command of the huge portion of the smart pho ne market beginning the smart phone revolution that persist to-date. The smart phone evolution was taken up a level higher by the subsequent introduction of the IPhone 4 and 5 and Apple currently ranks as the second biggest producer and market of smartphones globally. The initial smart phone cost $499 and although the debut price was considerably high, it was not the priciest phone on the market and it cost substantially less than some of the older but less developed mobile device on the market. However, this price proved too high to penetrate the mainstream market and as a result, the phones were mostly limited to an upper and middle class corporate and personal clientele. The second IPhone flagship model was the IPhone 4 series that offered significant improvements from the earlier 3G, and through it Apple introduced optical lamination, an interplane switching effectively scaled over the matching display sizes offered by the completion (Richie, 2013). Despite the challenges the de vice faced in the marketing as well as some technical difficulties, it was stated as the best smart phone ever by many. The latest model of IPhone, IPhone 5 was introduced in 2012 September (William 2013), and it was bigger smarter, lighter faster and the firm had used the experience from the glitches in previous IPhones to make the new one as flawless as possible. Customers received it enthusiastically and although its sales did not match rival Samsung galaxy III, they still performed considerably well on selling their phone (Gruman 2012). 4. Challenges facing the IPhone 4.1 Radical and Regular Upgrades Apple releases a new IPhone every year but despite that, many customers do not upgrade, but a significant number of customers have retained their IPhone 4 models owing to economic or speculative reasons (Swift 2010). Therefore, this problem is likely to keep affecting many of the firm’s clients and when they decide to make a shift, they may opt to buy a phone from a different firm such as Samsung or Microsoft. Apple customers often have to struggle to catch up with the firm’s rapid and on occasion drastic hardware upgrades (Associated Press 2013). Apples upgrades vary form one model to the other; however sometimes, the changes can be very subtle such that the newer is only slightly different or

Causes and Effects of Water Pollution in Lake Huron Essay

Causes and Effects of Water Pollution in Lake Huron - Essay Example Its drainage region is large in comparison to other Great Lakes since it covers parts of Ontario and Michigan lakes. Its waters are useful to several people who bound it especially the farmers. However, the Lake has been facing some water pollution challenges that make its waters disastrous. The ultimate aim of this context is to examine the sources that lead to pollution of Lake Huron and the Great lakes. It then looks at the effects of this pollution and winds up by providing recommendations on what can be done to save Lake Huron (Buchsbaum, 2009). Causes of Water Pollution on Lake Huron Several pollutants caused by human activities around the region have affected Lake Huron. Some of the most common pollutants are as mentioned below. Chemical Contamination Lake Huron is fed by contaminants, which initiate from several sources among them being spills, municipal discharges, industrial discharges, landfills, agricultural runoff and storm sewers (Krantz & Kifferstein, 2010). These cont aminants get into Lake Huron through several trails including atmospheric deposition, direct liberation and river discharge. In comparison to Lakes Ontario, Michigan and Erie, pollutant concentrations are comparatively low in Lake Huron. However, public health consultative exists concerning utilization of trout and all Areas of Concern (AOCs). Atmospheric Deposition Besides, its massive surface area, like the other Great Lakes, has made it susceptible to atmospheric deposition of pollutants. It has a large surface area and comparatively few regional pollutant point sources (Mahler, Metre & Callender, 2006). Loading to Lake Huron from water basis are stumpy of all the Great Lakes, but air basis are highest. Bio-accumulative Substances From the late 1970s to around 1990s, the concentrations of bio-accumulative matters like DDT, PCBs, dioxins, dieldrin, and furans turned down considerably in Lake Huron lake trout. Nevertheless, whereas the concentrations of DDT have persistently deteri orated, PCB concentrations have not fallen off considerably since the mid-1980s. DDE inclinations in Lake Huron herring gull eggs display a marked reduction in concentration since 1970s. According to other inclinations, concentrations decreased considerably in the late 1970s but continued to be comparatively stable (Mahler, Metre & Callender, 2006). Continuing basis of pollutants is mainly from sediments polluted by historic liberation, airborne deposition industrial and municipal librations and land runoff. Initially, there were six main Great Lakes regions of considerable environmental pollution or Areas of Concern (AOCs) on Lake Huron. The St. Mary River is named as an Area of Concern since it contains pollutants from municipal discharges and non point source contamination sources (Buchsbaum, 2009). Management of industrial point sources is developing, and pollution consignments are being minimized. The St. Clair River is named as an AOC because of the contamination difficulties on the eastern side of the river. Severn Sound and Spanish are the two other Canadian Areas of Concern that are reacting positively to the remedial activities and displaying recovery (Mahler, Metre & Callender, 2006). The only Area of Concern exclusively in Michigan, Saginaw Bay or river, is modeled as an AOC mainly because of polluted deposits and non point contamination sou

Molecular Mechanisms of Sepsis

Molecular Mechanisms of Sepsis Title: Protein-protein interaction network and functional module analysis to reveal the mechanism of sepsis in polytrauma patients Highlights: We explored the molecular basis of sepsis induced by polytrauma using PPI network. A total of 342 DEGs including 110 up- and 232 down-regulated genes were obtained. TRAF3 was related with the innate immune responses in sepsis. ITGB3 was the key gene involved in coagulation dysregulation in sepsis. CASP6 and RASA1 played key roles in the cell apoptosis mechanism of sepsis. Abstract Objective Sepsis represents the systemic inflammatory response to microbial infection. The pathogenesis of sepsis remains unclear. In this study, we aimed to explore the molecular mechanism of sepsis inpolytrauma patients. Methods The differentially expressed genes (DEGs) between the polytrauma patients with and without sepsis were identified by analyzing the GSE12624 microarray data using the limma package of R. The protein-protein interaction (PPI) network was extracted from the human PPI datasets by using MATLAB. The functional modules in the PPI network were identified by the MCODE network clustering algorithm. The KEGG pathway analysis was performed in each module. The phylogenetic tree was constructed using phylogeny inference package (PHYLIP). Result Total of 342 DEGs including 110 up- and 232 down-regulated genes were obtained. The PPI network identified several hub genes which had more interactions with others, such as TRAF3, ITGB3, CASP6 and RASA1. Further phylogenetic analysis indicated the high conservation of these hub genes. In the module analysis, four significant modules were identified. All the genes (COL1A2, FN1, ITGA2B, ITGB3 and CD36) in module 2 were enriched in extracellular matrix (ECM)-receptor interaction pathway. In module 4, CASP6 and CASP3 were enriched in apoptosis pathway. Conclusion We predicted genes such as TRAF3, ITGB3, CASP6 and RASA1 which were closely associated with sepsis induced by polytrauma. Among them, ITGB3 may play key role in the coagulation dysregulation of polytrauma patients with sepsis, and CASP6 and RASA1 may be the key genes in the cell apoptosis mechanism of sepsis. Keywords Sepsis, DEGs, GO, PPI network, phylogenetic tree Introduction Polytrauma is a syndrome of multiple injuries exceeding a defined severity with sequential systemic reactions that can lead to dysfunction or failure of remote organs and vital systems, which have not themselves been directly injured [1]. Sepsis, as one of the complications of polytrauma [2], is the systemic inflammatory response to microbial infection that often leads to increasing susceptibility to secondary infections, multiorgan failure, and death [3]. A sixteen years clinical study indicated that 10.2% of polytrauma patients infected sepsis during their hospital course [4]. Polytrauma is a major cause of morbidity and mortality in global and sepsis (3.1-17%) is one of the predominant causes of late death in polytrauma patients [5]. The disease severity is increasing according to the order of sepsis, severe sepsis and septic shock in the systemic inflammatory response syndrome (SIRS) [6]. Mortality has been reported to be as high as 45.6% for patients with severe sepsis or septic shock [7]. Based on the pathogenesis of sepsis, many therapies have been applied in the clinical practice such as antimicrobial therapy [8, 9] and hemodynamic support and adjunctive therapy [10, 11]. Currently, the Surviving Sepsis Campaign (SSC) has attempted to increase the awareness and establish the practice guidelines to improve the recognition and treatment for the patients with sepsis [12, 13]. At present, there are four approved mechanisms in the pathogenesis of sepsis [14]. The first one is dysregulated coagulation. Sepsis patients frequently manifest disseminated intravascular coagulation (DIC) with consumption of platelets and prolongation of clotting times [15]. The second one is inflammatory response. The inflammatory response is an important and central component of sepsis because the elements of response drive the physiological alterations that manifest as the SIRS [16]. Third, many cellular aspects become dysfunctional in sepsis which behave either excessive activation or depressed function [17]. The last one is metabolic alterations. It was reported that endogenous glucose production was markedly increased in the patients [18]. However, the specific molecular mechanisms of them remain entirely unclear. In this study, the differentially expressed genes (DEGs) between the polytrauma patients with sepsis and without sepsis were identified. Gene ontology (GO) analysis , protein-protein interaction (PPI) network and phylogenetic tree construction were performed to explore the molecular basis of sepsis induced by polytrauma. Materials and methods Microarray data The gene expression profile of GSE12624 based on the CodeLink UniSet Human I Bioarray platform (GE Healthcare/Amersham Biosciences) was downloaded from National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) database (http://www.ncbi.nlm.nih.gov/geo/). The dataset available in this analysis contained 70 samples including 34 polytrauma patients with sepsis and 36 polytrauma patients without sepsis. Data preprocessing and DEGs screening For the microarray data, Robust Multichip Average (RMA) in the Affy package of R was used to compute normalized expression measures from the raw expression values. Probe annotation was obtained by using the Bioconductor package. The limma package was used to identify the DEGs with p-value 1 [19]. GO enrichment analysis of DEGs GO analysis was performed using the DAVID online tool (http://david.abcc.ncifcrf.gov/) [20]. For GO enrichment of DEGs, we selected GOTERM_BP_FAT, GOTERM_CC_FAT and GOTERM_MF_FAT as the gene set categories. A p-value of less than 0.05 was set as the cut-off criterion. PPI network construction The human PPI datasets with 108477 interacting protein pairs were downloaded from PINA2 (http://cbg.garvan.unsw.edu.au/pina/interactome.stat.do) at December 26, 2013. The PPI networks of the DEGs in sepsis were extracted from the human PPI datasets by usingMATLAB [21]. The proteins in the network served as nodes and the degree of a node corresponded to the number of interactions with other proteins [22]. The protein with high degree was considered as the hub node. Identification of functional modules in PPI network PPI network visualization and network parameters evaluation were performed by using Cytoscape software. The modules were identified by the MCODE (a cytoscape plug-in) network clustering algorithm with the default parameters [23]. The module with score larger than 2 was considered as significant. KEGG pathway analysis of each module was performed by applying the DAVID annotation tool. Phylogenetic tree construction In this study, we constructed the phylogenetic tree based on the nucleotide sequences to investigate the sequence conservation of the DEGs whosedegree were large than 30. The BLAST program is used to search for homologous sequences of these DEGs. The DNA sequence of these DEGs and their homologous genes in FASTA format were obtained from the nucleic acid database in NCBI (http://www.ncbi.nlm.nih.gov/nuccore). The phylogenetic tree was constructed by using phylogeny inference package (PHYLIP) with the default parameters [24]. The gene conservation was estimated by the distance from gene to the phylogenetic tree root. Result DEGs between the patients with and without sepsis After statistical analysis of the microarray data, a total of 342 DEGs were screened out. Among them, 110 were down-regulated and 232 were up-regulated in sepsis. The top 20 significantly up- and down-regulated DEGs are shown in Table 1. GO enrichment analysis The 342 DEGs were significantly enriched into 95GOterms including 81 biological processes terms, 10 cellular component terms and 4 molecular function terms. The top 10 GO biological processes termswere mainly related to the purine base (purine base biosynthetic process, purine base metabolic process, purine nucleoside monophosphate biosynthetic process and purine ribonucleoside monophosphate biosynthetic process), nucleobase (nucleobase metabolic process and nucleobase biosynthetic process) and regulation of protein modification (regulation of protein modification process and positive regulation of protein modification process). The 10 significantly enriched GO terms of cellular component included four lumen related terms (organelle lumen, membrane-enclosed lumen, intracellular organelle lumen and nuclear lumen), two membrane related terms (extrinsic to membrane and plasma membrane part) and four other cellular component terms (peroxisome, microbody, nuclear body and Golgi apparatus) . For molecular function, four significant GO terms were enriched finally. They were acyl-CoA binding, sons of mothers against decapentaplegic homologue (SMAD) binding, aryl hydrocarbon receptor binding and potassium channel inhibitor activity (Table 2). PPI network of DEGs A PPI network consisting of 225 DEGs and 1048 non-DEGs is shown in Fig. 1. This network included 1145 gene nodes and 1273 interactions. The connectivity degree of each node in this PPI network was calculated and the results of top 20 nodes are listed in Table 3. Among them, the genes CRK (encoding CDC2 related protein kina), RASA1 (encoding RAS p21 protein activator 1), TRAF3 (encoding tumour-necrosis-factor receptor associated factor 3), ZHX1 (encode zinc-fingers and homeoboxes), ITGB3 (encoding integrin ÃŽ ²3), RPA1 (encoding replication protein A1), JAK3 (encoding Janus kinases 3), and CASP6 (encoding caspase-6) with the degree over 30 were selected as the hub genes. Module analysis of PPI network A total of 7 modules were constructed by using MCODE plug-in. After excluding the modules with the score less than 2, 4 significant modules were considered as functional ones associated with sepsis (Table 4). According to the Fig. 2, the numbers of nodes and edges were similar in each model. The detailed results of KEGG pathway analysis for each module are provided in Table 5. For module 1, no pathway was enriched in the KEGG pathway analysis. For module 2, a total of 14 significant enriched pathways were identified. Among them, all the genes in this module were enriched in the pathway of extracellular matrix (ECM)-receptor interaction. In addition, except CD36 (encoding glycoprotein IV), the other four genes (ITGB3 and ITGA2B encoding integrin ÃŽ ±IIbÃŽ ²3, COL1A2 encoding the ÃŽ ± 2 chain of type 1 collagen and FN1 encoding fibrinogen 1) were enriched in the focal adhesion and phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway. There were three significant enriched pathways in module 3. HIF1A (encoding hypoxia inducible factor-1), ARNT (encoding arylhydrocarbon receptor nuclear translocator) and ARNT2 (encoding arylhydrocarbon receptor nuclear translocator 2) were enriched in the pathway of renal cell carcinoma and pathways in cancer. HIF1A and ARNT were enriched in the pathway of Hypoxia-inducible factor 1 (HIF-1) signaling. For the module 4, five significant pathways were found. Among them, CASP3 (encoding caspase 3) and BIRC5 (encoding baculoviral IAP repeat–containing 5 and also called survivin) were enriched in the pathway of colorectal cancer, hepatitis B and pathways in cancer. CASP6 and CASP3 were enriched in apoptosis pathway. CASP3 and RASA1 were enriched in the mitogen-activated protein kinase (MAPK) signaling pathway (Table 5). Phylogenetic tree analysis Based on the result of PPI network analysis, the selected hub genes were chosen to construct the phylogenetic tree. The phylogenetic tree of ZHX1 was unable to be constructed, as only three homologous sequences were searched out. The phylogenetic trees of the other seven hub genes were constructed by the DEGs and their top nine significant homologous genes. The results showed that CRK, RASA1, TRAF3, ITGB3, RPA1 and CASP6 were the genes that were closer to tree roots indicating that the conservation of these genes was high during evolution. However, the conservation of JAK3 was low because of appearing in the late period of evolution (Fig. 3). Discussion Currently, sepsis remains a serious clinical problem. The four approved mechanisms of sepsis were dysregulated coagulation, inflammatory response, and cellular dysfunctional and metabolic alterations. However, the specific molecular mechanisms are still incompletely understood. For better understanding the pathogenesis, we identified and analyzed the DEGs between the patients with and without sepsis. As a result, a total of 342 DEGs including 110 up-regulated genes and 232 down-regulated genes were found. These genes were significantly enriched in GO terms including purine base biosynthetic process, regulation of protein modification process and peroxisome. Among them, the process of purine base biosynthesis is the most significantly enriched process. It was reported that de novo purine biosynthesis was essential for infectivity, growth and virulence of many bacteria in mammals [25]. The pathogenesis of sepsis was related with the bacterial infection [26]. Therefore, the purine base biosynthesis process may associate with sepsis based on the tissue response to bacterial infection. For the regulation of protein modification, Wu et al. reported that the alterations in the phosphorylation of myofibrillar proteins and the Ca2+ sensitivity of myofibrillar ATPase might contribute to alter cardiac function during the progression of sepsis [27]. The cardiac dysfunction was the clinical characteristic in severe sepsis and septic shock [28]. Thus, the phosphorylation of myofibrillar proteins may be related with the sepsis-induced cardiac dysfunction. Furthermore, we mapped the DEGs to the PPI network and identified high conserved hub genes. Among them, the high conservation of CRK, RASA1, TRAF3, ITGB3, RPA1 and CASP6 were proved by the phylogenetic tree analysis. They may be the crucial genes in the pathogenesis of sepsis. For TRAF3, it is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family [29]. This protein participates in the activation of the innate immune response [30]. In the PPI network, TBK1 (encoding TANK-binding kinase 1) was a non-DEG interacted with TRAF3. It was reported that TIR domain-containing adaptor-inducing IFN-ÃŽ ² (TRIF) could interact with noncanonical IKKs (IKKà Ã‚ µ and TBK-1) and IKKÃŽ ¹ (also called IKKà Ã‚ µ) through TRAF3 in the Toll-like receptors (TLR) signaling pathway [31]. The innate immune system constitutes the first line of defense by rapidly detecting invading pathogens through the TLR [32] and is a danger signal in systemic inflammatory response syndrome and sepsi s [33]. Thus, TRAF3 may be the mediator of innate immune responses in sepsis induced by polytrauma. We also performed the modular analysis of the PPI network and four functional modules were identified. Based on the result of the KEGG pathway analysis of each module, we found that the pathways in module 2 and 4 were more related with sepsis. The ECM-receptor interaction pathway was the most significant pathway in module 2 and all the genes of this module were enriched in this pathway. Fibronectin and collagen are the components of ECM [34]. Integrin family are the receptors transducing signals from the ECM [35]. Among them, integrin ÃŽ ±IIbÃŽ ²3 is the platelet integrin promoting theaggregation of platelets [36-38]. Moreover, it was reported that collagen type I could induce the aggregation of platelet [39]. Integrin ÃŽ ±IIbÃŽ ²3 is one of the platelet collagen receptors in platelets [40]. It was reported that platelet-specific elements initiated at the cytoplasmic domains of integrin ÃŽ ±IIbÃŽ ²3, which was a signal that leaded to conformational changes within the extracellular do mains of integrin and expression of the fibrinogen receptor, then the simultaneous occupancy on adjacent platelets of receptors with dimeric fibrinogen molecules leaded to platelet aggregation [41]. In addition, CD36 is spatially associated with the ÃŽ ±IIbÃŽ ²3 integrin on the surface of platelets [42]. Thus, we speculated that the binding of collagen type I and ÃŽ ±IIbÃŽ ²3 might need the participation of CD36, and then conformational changes within the extracellular domains of integrin and the binding between fibrinogen and fibrinogen receptor could lead to platelet aggregation. Disseminated platelet aggregation is one of the characteristics of the DIC in sepsis [43, 44]. The up-regulated expression of ITGB3 in sepsis may lead to the disseminated platelet aggregation. Hence, we concluded that the coagulation dysregulation in the polytrauma patients with sepsis may be associated with the increase of disseminated platelet aggregation caused by the up-regulated expression of ITGB3. Thus, ITGB3 may play key roles in the coagulation dysregulation of the polytrauma patients with sepsis. Hub nodes CASP6 and RASA1 were predicted to be closely interacted with each other in module 4. Besides, CASP3, TOP1, BIRC5 and AURKB (Aurora B kinase) were also included in module 4. Among them, CASP6 and CASP3 were enriched in apoptosis pathway. It was reported that CASP6 may be associated with the cell apoptosis in sepsis [45] and blocking caspases might have some beneficial effects in decreasing cell apoptosis in sepsis [46]. Thus, we further confirmed that the up-regulated expression of CASP6 may promote cell apoptosis in sepsis. Besides, TOP1 is cleaved late during cell apoptosis by CASP6 and CASP3 [47]. The TOP1 cleavage complexes contribute to cell apoptosis [48]. Therefore, the increase of these complexes induced by the up-regulated CASP6 can promote the cell apoptosis in sepsis. Moreover, full-length TOP1 could induce DNA cleavage by single-strand breaks which is the signal of cell apoptosis [49, 50]. Therefore, the exaggerated gene expression of TOP1 in our study might cont ribute to cell apoptosis in sepsis. In addition, it was reported that CASP3 could modulate a given set of proteins to generate, depending on the intensity of the input signals, opposite outcomes (survival vs death) through differential processing of RASA1 [51]. Some articles reported that low CASP3 activity leaded to the cleavage of the RASA1 protein into an amino-terminal fragment [52, 53]. RASA1 bound BIRC5 is a bifunctional protein complex that can suppress cell apoptosis and regulated cell division, so as to generate anti-apoptotic signals [54]. AURKB exists in a complex with BIRC5 [55]. Considering the up-regulated expression of RASA1 and AURKB, we speculated that there may be a switch mechanism of CASP3-RASA1 in cell apoptosis and BIRC5 and AURKB might play roles in the anti-apoptosis mechanism of RASA1. In summary, CASP6 and RASA1 are the key genes in the pathogenesis of sepsis induced by polytrauma. Conclusion In this study, we obtained four key genes related with pathogenesis of sepsisinduced by polytrauma. Among them, TRAF3 was related with the innate immune responses in sepsis,ITGB3 may play key role in the coagulation dysregulation of the polytrauma patients with sepsis and CASP6 and RASA1 were associated with the mechanism of cell apoptosisin sepsis. For further investigating the association of these hub nodes with sepsis and verifying the role of the interactions among the genes in the pathogenesis of sepsis, more studies are required in the future.